A Model of Autophagy Size Selectivity by Receptor Clustering on Peroxisomes
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چکیده
منابع مشابه
A Model of Autophagy Size Selectivity by Receptor Clustering on Peroxisomes
Selective autophagy must not only select the correct type of organelle, but also must discriminate between individual organelles of the same kind so that some but not all of the organelles are removed. We propose that physical clustering of autophagy receptor proteins on the organelle surface can provide an appropriate all-or-none signal for organelle degradation. We explore this proposal using...
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When subcellular organelles are degraded by autophagy, typically some, but not all, of each targeted organelle type are degraded. Autophagy selectivity must not only select the correct type of organelle, but must discriminate between individual organelles of the same kind. In the context of peroxisomes, we use computational models to explore the hypothesis that physical clustering of autophagy ...
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Degradation of plant peroxisomes by autophagy
Peroxisomes play a critical role in many metabolic pathways during the plant life cycle. It has been proposed that the transition between different types of peroxisomes involves the degradation of obsolete peroxisomal enzymes via proteolytic activities in the peroxisome matrix, the cytosol, or the vacuole. Forward and reverse genetic studies recently provided evidence for autophagic degradation...
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Selective macro-autophagy is an intracellular process by which large cytoplasmic materials are selectively sequestered and degraded in the lysosomes. Substrate selection is mediated by ubiquitylation and recruitment of ubiquitin-binding autophagic receptors such as p62, NBR1, NDP52 and Optineurin. Although it has been shown that these receptors act cooperatively to target some types of substrat...
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ژورنال
عنوان ژورنال: Frontiers in Physics
سال: 2017
ISSN: 2296-424X
DOI: 10.3389/fphy.2017.00014